Electrochemical coating of metallic medical devices

Abraham J. Domb 2Galit Shustak Zehava Weiss Stanislaw Słomkowski 1Mariusz Gadzinowski 1Dani Mandler 2

1. Polish Academy of Sciences, Center of Molecular and Macromolecular Studies (CMMS-PAS), Sienkiewicza 112, Łódź 90-363, Poland
2. The Hebrew university of Jerusalem (HUJI), Ein Kerem Campus, Jerusalem 91120, Israel

Abstract

Electropolymerization of medical devices such as cardiovascular stents may posses advantages including: simple and reproducible process with the ability to control the thickness, adherence and composition of the coating by the duration and intensity of the applied current, the monomer composition and concentration, the solvent and the reaction conditions. The properties of the polymer can also be controlled by copolymerization of different monomers, grafting substituents to a functionalized polymer, and by entrapping biomolecules. The synthesis of a range of pyrrole based monomers and their electrocoating onto stainless still surfaces was investigated. N-substituted pyrrole monomers with C1 to C18 alkyl chains and polyethylene glycol chains were synthesized in good yields and purity. Electropolymerization of these monomers provided uniform coatings with different hydrophobicities. Current studies focus on the incorporation of drugs in the coated device for the release from the surface.

 

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Presentation: invited oral at E-MRS Fall Meeting 2004, Symposium B, by Abraham J. Domb
See On-line Journal of E-MRS Fall Meeting 2004

Submitted: 2004-04-29 14:56
Revised:   2009-06-08 12:55