Hybrid polymeric materials for medical applications

Stanislaw Słomkowski ,  Teresa M. Basinska ,  Beata Miksa ,  Ewelina Przerwa 

Polish Academy of Sciences, Center of Molecular and Macromolecular Studies (CMMS-PAS), Sienkiewicza 112, Łódź 90-363, Poland

Abstract

Materials used for medical applications, in particular for medical diagnostics devices, often should have a set of properties difficult to obtain for polymers, metals or ceramics alone. However, in many instances the required properties could be achieved for combinations of materials belonging to the mentioned above classes into polymer-metal or polymer-ceramic hybrids. During presentation we will report on fabrication of hybrid materials based on polymeric nano- and microparticles, the materials developed for using them for production of biosensors. A set of fundamental properties of materials for construction of detectors of biosensors includes: (i) the ability to immobilize chosen bioreceptors (e.g., enzymes or antibodies) on selected surfaces in a way allowing retention of their bioactivity, (ii) suitability for transmission of electrical, optical or other signals accompanying interaction of receptors with an analyte, (iii) an easy, simple and inexpensive production. In our laboratory we developed methods for controlled synthesis of polymeric particles with diameters in a range from ca 100 nm to few micrometers - particles with interfacial layer containing reactive hydroxyl, carboxyl or aldehyde groups suitable for covalent immobilization of proteins and oligonucleotides. Syntheses of these particles and methods suitable for immobilization of biomacomolecules onto them will be presented. Convenient and simple methods for physical adsorption and covalent immobilization of particles onto glass, quartz, mica, and onto other substrates have been developed. Special attention was concentrated on fabrication of hybrid polymer nanoparticle – inorganic substrates with controlled morphology of particle monolayers. In the lecture we will describe investigated models of biosensors constructed on the basis of the mentioned above hybrid materials and discuss other potential applications of these materials for fabrication of diagnostic devices.

 

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Presentation: invited oral at E-MRS Fall Meeting 2005, Symposium E, by Stanislaw Słomkowski
See On-line Journal of E-MRS Fall Meeting 2005

Submitted: 2005-05-19 21:03
Revised:   2009-06-07 00:44