Effect of High Hydrostatic Pressure on Ability of Neutrophils to Phagocytize

Natalya V. Shishkova 

National Academy of Sciences of Ukraine, Donetsk Technical-Physical Institute, R. Luxemburg 72, Donetsk 83114, Ukraine


Shishkova N.V. (1), Donchenko L.I. (2), Barbashov B.I. (1)
(1) Donetsk Physics & Technology Institute of National Academy of Sciences of Ukraine, 72, R.Luxemburg, St, 83114, Donetsk, Ukraine
(2) Scientific-Research Institute of Traumatology & Orthopedic of Donetsk State Medicine University, 106, Artema St., 83048, Donetsk, Ukraine
For recent years the studies of high hydrostatic pressure effect on different cells and change of their ability to some functions have had an increasing interest. Such effects can be considerable and depend on many factors.

The aim of present investigation was to study the neutrophil ability to phagocytize after high hydrostatic pressure action.

The studies were carried out for such many component system as a blood plasma, which was subjected to the high pressure treatment up to 500 MPa.
Effect of the oxidation-recovery processes at the neutrophil membrane level with the use of the NBT-reaction has been studied.
The ability of phagocytizing cells (polymorphonuclear neutrophils) of human blood after high pressure treatment has been determined.
It was established that oppression of phagocytic activity of neutrophils was proportional to the applied pressure value. On our opinion it was stipulated by disorder of mechanisms of oxidation-recovery reactions at the cell membrane level.


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Presentation: poster at High Pressure School 2001 (4th), by Natalya V. Shishkova
See On-line Journal of High Pressure School 2001 (4th)

Submitted: 2003-02-16 17:33
Revised:   2009-06-08 12:55