Biocompatibility of materials with living organism onto medical implants was the first step to develop the next examinations. The results of these researches have not proved exactly this assumption. Biocompatibility and biotolerance of diamond and graphite have been observed on macroscopic level (in vivo) in the pioneer researches with carbon coatings.
Carbon Particles - Diamond Powder Particles (DPP) and Graphite Particles have been examined on molecular, macroscopic and clinical level.
On the molecular level Diamond Powder Particles (DPP) have very high bioactivity. This activity involves toxic processes of cell membrane and damage of nucleus. DPP inhibits these toxic reactions and prevents the different human disorders, for example: Alzheimer Disease, Parkinson Disease, Diabetes Mellitus, Myocardial Infarctus.
The comparison between Graphite Particles and Diamond Particles shows that mainly graphite has very high biocompatibility with a living organism on the molecular level but its bioactivity is not significant.
In vivo examinations with Carbon Particles proved the biocompatibility with living organism ( the contact reaction with peritoneum) and these results indicate that only DPP is bioactive.
In vivo DPP inhibits inflammatory process in peritoneum stimulated by LPS (lipopolysaccharide).
Graphite Particles are neutral for this reaction.
The clinical examination (patch tests) proved the very high biotolerance of both Carbon Particles. The results show the absence of Irritation Reaction (IR) and Allergic Reaction on the skin in patients with allergy after exposure to Carbon Particles in the patch tests.
Graphite Particles is neutral for this reaction.
The clinical examination (patch tests) proved the very high biotolerance of both Carbon Particles. The results show the absence of Irritation Reaction (IR) and Allergic Reaction on the skin patients with allergy after exposition of Carbon Particles in the patch tests.