Ferrimagnetic DP-Bioglass Particles Modified with Polyethylene Glycol and Folic Acid Used for Drug Delivery Process

Min-Hua Chen 1Chung-King Hsu 1Feng-Huei Lin 2Leszek Stobinski Jerzy Peszke 3

1. Natinal Taipei University of Technology (NTUT), 1, Sec. 3, Chung-Hsiao E. Rd.,, Taipei 106, Taiwan
2. National Taiwan University (NTU), Roosevelt Rd., Taipei 106-17, Taiwan
3. Jan Długosz Academy, Al. Armii Krajowej 13/15, Częstochowa 42-200, Poland

Abstract

DP-bioglass particles are biodegradable material which can be used as bioactive material in soft tissue and bone treatment. It has often been used in orthopedics and plastic surgery. Recently, DP-bioglass was also used as a carrier for drug and gene delivery systems. Additionally, ferrimagnetic DP-bioglass can be a potential candidate for magnetic-induction hyperthermia, by using a magnetic field. The aim of this work is the preparation and characterization of surface-modified DP-bioglass particles. Their surface should be modified by polyethylene glycol (PEG) and folic acid (FA) to improve its intracellular uptake and ability to target specific cells. The first PEG-FA complex was synthesized using carbodiimide (DCC) to link PEG with FA. Then PEG-FA molecules were immobilized on the surface of DP-bioglass particles, which were initially modified by amino-silane (AEAPS) as a coupling agent. FTIR, TGA and NMR were used to reveal this immobilization process. Biological studies have shown that ferrimagnetic DP-bioglass particles coated with PEG-FA complex significantly enhance their intracellular uptake by targeted cells.

 

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Presentation: Poster at E-MRS Fall Meeting 2006, Symposium J, by Leszek Stobinski
See On-line Journal of E-MRS Fall Meeting 2006

Submitted: 2006-05-15 16:43
Revised:   2009-06-07 00:44