A new analgetic drug AV-101 was immobilized to calcium-alginate gel beads with average diameter of 1 mm. A series of alginate gel contains with various mannuronic/guluronic (M/G) ratios was selected to control the diffusion of the drug. Release of the drug from the alginate beads in vitro into physiological sodium-containing solutions was studied. As found, a discontinous time of the Fickian diffusion of the drug depending on the M/G ratio was folowed by a burst release of the remaining drug. The burst release was due to a swift disintegration of calcium alginate with the exchange on sodium ions. The preceding discontinuous lag time promotes a free dissociate exchange of sodium-calcium in M units, while the burst disintegration leads to fast dissociation of G units. The lag time can be controlled by M/G ratio of calcium alginate gels. The lag time increases if a content of M units decreases. The increase of M blocks was led to more extensive swelling of the alginate gel beads. Such way could be promising for a controlled drug delivery or the use in implants with controlled drug effect.

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