Magnetic Encapsulates: Nd-Fe-B@C and Fe@C for drug delivery systems.

Michal J. Wozniak 1Michał Bystrzejewski 3Andrzej Huczko 3Waldemar Kaszuwara 1Jan Kozubowski 1Hubert Lange 3Marcin Leonowicz 1M. Zdrojek 2

1. Warsaw University of Technology, Faculty of Materials Science and Engineering (InMat), Wołoska 141, Warszawa 02-507, Poland
2. Warsaw University of Technology, Faculty of Physics, Koszykowa 75, Warszawa 00-662, Poland
3. Warsaw University, Faculty of Chemistry, Pasteura 1, Warszawa 02-093, Poland

Abstract

Carbon nanostructures containing ferromagnetic material could find different application such as, drug delivery systems and medical contrast elements.
In the current work, magnetic encapsulates: Nd-Fe-B@C and Fe@C for drug delivery systems are described.
HRTEM investigation shows the product is composed of metal crystals encapsulated in carbon shells. The size of the particles is in the range of 10-100nm. XEDS spectra indicate the carbon encapsulates contain Fe and Fe-Nd crystals. MFM images show that nanoparticles demonstrate ferromagnetic behaviour.
After the acid treatment on the surface of encapsulates COOH groups should be present. These COOH groups can be easily substituted by drug molecules and targeting ligand molecules. The presence of the carbon shell protect magnetic nanocrystals from biodegradation when exposed to the biological systems. The encapsulates can be inject in the blood vessels and target with external magnetic field what will be discussed. The interaction between encapsulates and human living cells will be discussed as well.

 

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Presentation: poster at E-MRS Fall Meeting 2005, Symposium B, by Michal J. Wozniak
See On-line Journal of E-MRS Fall Meeting 2005

Submitted: 2005-05-05 13:33
Revised:   2009-06-07 00:44