Nowadays, new drugs, with increasing therapeutic efficacy, are synthesized. It often happens that the drug has a high activity at the target, but has a poor solubility in aqueous solutions or damages healthy cells. The solution to these problems is using properly selected carrier of the active substance. It was shown that star copolymers can be excellent drug carriers through their unique solution behavior and enhanced cell uptake. Copolymers having in its structure amine groups were bind to fluorescein isothiocyanate. Isothermal titration calorimetry technique was used to provide a full thermodynamic data for description of these reactions. Collected thermodynamic parameters were compared, which resulted on selecting the best drug carrier.

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