This study was conducted to investigate effects of sodium fluoride (NaF) on brain (cerebral hemisphere, cerebellum) of rats and its possible amelioration by triphala. Adult female Wistar rats (Rattus novergicus) were administered sodium fluoride (NaF) and triphala at the dose of 10mg/kg and 30mg/ kg body weight respectively for 30 days. A significant decline in body and brain tissue weights after NaF treatment was noted. The decreased succinate dehydrogenase (SDH) activity indicates an alteration in mitochondrial structure and function by fluoride poisoning affecting energy metabolism. An increase in the total lipid could be the result of the inhibition of enzymes and reduction of fatty acid synthesis. Further, increased lipid peroxidation indicated an oxidative stress in the brain. There effects were correlated with histological changes and accumulation of fluoride in these neural tissue. However, these changes were ameliorated by co-supplementation of triphala alongwith NaF in rats, because of antioxidant properties of the herbal product. Hence, triphala alleviates NaF induced neurotoxicity in rats.

1. PRESENTATION: Role of triphala on fluoride neurotoxicity in the rat., Zip archive data, at least v2.0 to extract, 0MB
2. PRESENTATION: Role of triphala on fluoride neurotoxicity in the rat., Zip archive data, at least v2.0 to extract, 0MB

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1. Mitigating effects of triphala on fluoride non-endocrine toxicity.
2. Triphala an excellent antioxidant in mitigation of fluoride endocrine toxicity.