Synthesis and properties of up-converted NaYF4: Er, Yb nanoparticles for biomedical applications
|Bożena Sikora 1, Krzysztof Fronc 1, Sebastian Szewczyk 2, Izabela Kamińska 1, Anna Baranowska-Korczyc 1, Kamil Koper 3,4, Kamil Sobczak 1, Bohdan Paterczyk 5, Tomasz Wojciechowski 1, Roman Minikayev 1, Remigiusz Worch 1, Wojciech Paszkowicz 1, Piotr Stępień 3,4, Danek Elbaum 1|
1. Institute of Physics, Polish Academy of Sciences, Warsaw 02-668, Poland
We synthesized potential biosensors, based on Er, Yb doped NaYF4 nanoparticles, with up-conversion of infrared light capable to emit in the visible and ultraviolet range. They could be potentially applied for targeted therapy in cancer, through up-conversion to the ultraviolet radiation. Biological systems excited by the near infrared energy exhibit less autofluorescence than if excited by the visible or the ultraviolet light. Visible emission permits to observe physiologically relevant processes within cells, and the emission of the ultraviolet light allows for the selective elimination of cancer cells by generating free radicals.
Acknowledgements: The research was partially supported by the European Union within European Regional Development Fund, through grant Innovative Economy (POIG.01.01.02-00-008/08) and was partially supported by the grant from the Polish National Centre for Research and Development NR13004704 and Center of Excellence. This work has been done in the NanoFun laboratories co-financed by the European Regional Development Fund within the Innovation Economy Operational Programme, the Project No. POIG.02.02.00-00-025/09/.
Presentation: Poster at Nano-Biotechnologia PL, by Bożena Sikora
See On-line Journal of Nano-Biotechnologia PL
Submitted: 2012-06-28 11:32 Revised: 2012-09-12 13:12