Carbon nanotubes applications for drug and gene delivery

Leszek Stobinski 1Piotr Tomasik 2Urszula Narkiewicz 3

1. Polish Academy of Sciences, Institute of Physical Chemistry, Kasprzaka 44/52, Warszawa 01-224, Poland
2. Cracow College of the Health Promotion, Cracow, Kraków 31-531, Poland
3. West Pomeranian University of Technology, Szczecin (ZUT), Szczecin 70-310, Poland

Abstract

The world production of carbon nanotubes reaches recently 2000 Mg/year. However, the world demand for CNTs material nowadays reaches hardly 300 Mg/year resulting in a considerable oversaturation of the market. Consequently, challenge is generated for scientists and manufacturers to find new, efficient applications for this fascinating material. Medicine is one of potential application area, where CNTs can be applied in, for instance, drug delivery systems, gene transfection and scaffolds for tissue regeneration. However, thus far poorly understood effects of CNTs on human organism requires detailed risk analysis and balancing potential risks and benefits from such applications.

              In the case of industrial applications of CNTs it is necessary to examine thoroughly  in this respect every step of such involvement of CNTs starting from their manufacturing through their functionalization, incorporation into a matrix (e.g. polymer), checking relevant properties of final products, then methods of their administration and, finally, after the product death also their degradation. Despite a technical feasibility study of the scale up-grading a careful analysis of possible risks for human health and environment at each stage from manufacturing to the final product, recycling and/or destruction is indispensable.

 

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Presentation: Invited oral at Nano-Biotechnologia PL, by Leszek Stobinski
See On-line Journal of Nano-Biotechnologia PL

Submitted: 2012-06-13 14:15
Revised:   2013-02-13 17:47