The creation of biomimetic support structures capable of supporting transmembrane proteins in their active form has proven to be a challenging task.  The inherent structural and compositional complexity of the plasma membrane makes the task of creating a synthetic equivalent difficult.  Issues such as the composition and morphology of supporting underlayers and the attachment of a biomimetic layer to an interface are central to success.  Much of the recent focus of our group has been on methods for binding lipid adlayers to interfaces while retaining fluidity.  A substantial concern for such systems is the extent to which the interfacial structure is influenced by the interface binding chemistry and its immediate environment.  An overview of recent advances in this area will be presented.

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1. Triple Phase Boundary Photo-Voltammetry: Resolving Rhodamine B Reactivity in 4-(3-Phenylpropyl)-Pyridine Microdroplets
2. Strategies for Self-Assembly of Phospholipids at Interfaces
3. Understanding and Controlling Curvature and Intermolecular Interactions in Biomimetic Membranes
4. Probing interfacial organization in planar lipid bilayers using tethered pyrene
5. Immobilization of molecules: From self-assembled monolayers to polymeric hollow structures
6. Probing organization and communication at layered interfaces
7. Design, Synthesis and Characterization of Monomolecular Interfacial Layers