New Nano-Sized Sensing Drug and Its Medical Application

BREZOI A. Dragos Viorel 1ION Rodica-Mariana 1,2

1. "Valahia" University of Targoviste - Faculty of Materials Science and Engineering, Unirii Avenue, Targoviste 130082, Romania
2. National Institute for Chemical and Petrochemical Research, Bucharest 060021, Romania

Abstract

Nanomedicine is the application of nanotechnology to the diagnosis and treatment of human disease. This discipline has the potential to change medical science dramatically, as demonstrated, for example, by an innovation in cancer imaging that uses novel diagnostic agents synthesized from nanoparticles. We are conducting research on cluster-based materials for future medical applications. The design of a multifunctional photosensitive particle that is stable and highly efficient will be key to this novel medical application and in the photodynamic treatment (PDT), especially. Three consecutive processes occur during the PDT treatment: initial consumption of oxygen through the photodynamic process; pathophysologic alterations in regional blood supply (hypoxia) and total vascular occlusion (ischemia). The effect of a new drug as TSPP-Sil-TiO2 was studied in this paper. By coupling with TiO2, TSPP is loosing the proper absorption bands, due to the chemical bonds SO2-NH, present in the new synthesized system. The UV-Vis spectrum of the new system indicates J-aggregate form suitable for biomedical applications. The particle size and the morphology of TSPP-Sil-TiO2 nanoparticles in acrylate matrix were investigated with AFM. The images of TSPP-Sil-TiO2 nanoparticles in polymer matrix have been compared with TiO2 nanoparticles alone. We implanted cancer cells under the skin of mice to cause tumors to form. When the size of the tumor grew to about 0.5 cm, it was injected a solution containing fine particles of TSPP-Sil-TiO2. After 2 or 3 days, were cut open the skin to expose the tumor and irradiated it. The treatment clearly inhibited the tumor growth. A further marked antineoplastic effect was obtained.

 

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Presentation: poster at E-MRS Fall Meeting 2004, Symposium G, by BREZOI A. Dragos Viorel
See On-line Journal of E-MRS Fall Meeting 2004

Submitted: 2004-04-26 15:02
Revised:   2009-06-08 12:55