A bit of physics in our understanding of the cell and tissue interaction with scaffolds

Małgorzata Lewandowska-Szumieł 

Medical University of Warsaw, Department of Biophysics and Human Physiology, Chałubińskiego 5, Warszawa 02-004, Poland

Abstract

The selected topics will be brought up in order to draw attention to the fact that the physical interaction between cell and scaffold is an important aspect of tissue engineering hybrid system consisting of a nonviable scaffold and living cells. Particularly, cell “feeling” of the support stiffness will be discussed on the basis of the recent scientific reports and the results from our group. Some attention will be paid to the new findings concerning mechanoreceptors of bone cells based on the patch-clamp methodology.

On the other hand, application of methods, which detect physical phenomena, to investigations of tissue organized inside the scaffold in vivo will be exemplified by a detection of bone formation in our tissue engineered product by means of the electron paramagnetic resonance (EPR).

 

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Presentation: Invited oral at E-MRS Fall Meeting 2008, Symposium L, by Małgorzata Lewandowska-Szumieł
See On-line Journal of E-MRS Fall Meeting 2008

Submitted: 2008-07-31 10:27
Revised:   2009-06-07 00:48