Pressure is always involved in Solvothermal and Hydrothermal Processes( autogeneous our imposed pressure). Consequently it is necessary to take into account different factors induced by such a parameter: the weak energy involved by pressure, the negative DV volume difference between the final state and the starting state value leading to the denser phases, the improvement of reactivity. Due to the small energy conveyed by pressure such a parameter can be used in developing nano-bio-materials with low thermal stability. It is therefore possible the development of research at the interface between different domains, such as: Hybrid  Materials (inorganic chemistry/Organic chemistry); Hybrid Systems (nano-chemistry/Biosciences). Optimisation is required for: physical-chemical properties of the precursors and solvent as well as the thermodynamic parameters P, T.

Original results on the synthesis of complex hybrid inorganic-organic systems with applications in nanomedicine are presented.

Acknowledgment: Romanian Agency for Scientific Research for financial support in the frame of Research for Excellence contracts 46-ReteBdent, 16-TECOREMED and COST D30 – High pressure Tuning of Materials.

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