Novel Biodegradable and Biocompatible Polymers for Anti-cancer Drug Delivery Systems

Zbigniew Jedliński 

Polish Academy of Sciences, Centre of Polymer Chemistry (CCHPPAN), Curie-Skłodowska 34, Zabrze 41-800, Poland

Abstract


Polymeric materials are playing nowadays an important role in medical applications as implants in reconstructive surgery and in drug delivery systems. However many natural polymers like cellulose and its derivatives, starch, hyaluronic acid and many others polymers produced in the nature being biocompatible, show some drawbacks as very high molecular weight, broad molecular weight distribution and not reproducible biological properties.
Therefore the natural copolymer of R,3-hydroxybutyric acid marketed by American Company Zeneca under the trade name Biopol, which is the biodegradable analog of natural polymer could be used only for production of packing materials.
In my lecture biodegradable and biocompatible polymeric materials are presented, which have been recently used in novel drug delivery systems. Drug delivery systems with suitable polymers us drug carriers show new vistas in chemotherapy. Using discovered in our laboratory catalyst system we are able to synthesized supramolecular polymeric anticancer drug conjugates and drug nano-dispersion.
Using this novel approach to drug delivery, the drug activity is increased and some side effects e.g. cardiotoxicity can be eliminated.


The useful discussions and cooperation with prof. P. Grieb (Institute of Experimental and Clinical Medicine PAS, Warsaw), prof. J. Kawiak (Department of Clinical Cytology, Medical Center of Postgraduate Education, Warsaw) and prof. Z. Krawczyk (Institute of Oncology, Gliwice) as well as financial support by KBN 7 T08 E 059 are acknowledged.

References:
1. Z. Jedlinski, J. Polym. Sci. Part A: Polym. Chem., 40, 2158 (2002)
2. Z. Jedlinski, Accounts Chem. Res., 31, 55 (1998)

Presentation: oral at E-MRS Fall Meeting 2003, Symposium E, by Zbigniew Jedliński
See On-line Journal of E-MRS Fall Meeting 2003

Submitted: 2003-06-11 13:28
Revised:   2009-06-08 12:55
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